A Upper left corner: two-point correlations in the radial positions between genomic regions. Lower right corner: two-point correlations in angular orientations around the long axis. B Upper left corner: two-point correlations between long-axis positions for wild-type cells. Lower right corner: the same correlations for a model not constrained by Hi–C data, but with a tethered origin (tethered random polymer). C Correlations in the long-axis positions of genomic regions derived from Hi–C data26 obtained for two modified conditions: cells treated with rifampicin to block transcription (upper left corner), and Δsmc cells (lower right corner).