Table 2 Cox proportional hazard regression analyses for 5-year survival.

From: RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

Clinicopathological features Multivariate analysis Un-variate analysis
HR 95% CI P value HR 95% CI P value
Age
   <60 years vs. >60 years 0.487 0.316–1.728 0.485 0.079 0.444–2.960 0.778
Gender
   Male vs. female 0.239 0.220–2.483 0.625 0.264 0.268–2.159 0.607
TNM stage
   I vs. II and III 0.434 0.281–1.879 0.510 11.751 0.158–0.605 0.001
Tumor size
   ≤5 cm vs. >5 cm 0.985 0.718–2.753 0.321 0.659 0.379–1.495 0.417
Differentiation
   Poor vs. well 4.579 0.192–0.930 0.032 7.244 0.164–0.752 0.007
Cirrhosis
   Absent vs. present 0.322 0.282–2.009 0.570 2.579 0.852–4.993 0.108
Vascular invasion
   Absent vs. present 3.283 0.115–1.089 0.070 21.503 0.291–13.916 <0.001
RALYL expression
   Absent vs. present 3.936 0.245–0.992 0.047 4.204 0.344–0.969 0.040
CD133 upregulation
   No vs. yes 4.670 0.218–0.928 0.031 5.057 0.236–0.906 0.025
TGF-β2 upregulation
   No vs. yes 0.369 0.347–1.746 0.543 9.186 0.183–0.695 0.002
  1. Cox regression analysis. Statistical significance (P < 0.05) is shown in bold. CI, confidence interval; HR, hazard ratio.
  2. CI confidence interval, HR hazard ratio.