Fig. 8: PGC clusters disperse by directing individual migratory polarity outward to collectively remove cell–cell adhesions. | Nature Communications

Fig. 8: PGC clusters disperse by directing individual migratory polarity outward to collectively remove cell–cell adhesions.

From: Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo

Fig. 8

PGC clusters disperse by utilizing Tre1−/− to interpret a presumed migratory cue presented at the exterior of the cluster to orient and stabilize individual migratory polarity radially from the cluster. Sustained polarization of myosin II contracts posterior cortices into foci as PGCs separate. Across the cluster, the opposing directions of PGC migration facilitate a collective response by aligning diametric migratory forces, akin to breaking a rope (cell adhesions) by pulling both ends apart. E-cadherin remains present on the cell membrane throughout. In the absence of Tre1−/−, PGC motility is randomized, resulting in a significant decrease in migration persistence. Clusters remain intact as PGCs are unable to orient their migration in a given direction for a sufficient time period to detach.

Back to article page