Fig. 8: Heterogeneity analysis in additional organs. | Nature Communications

Fig. 8: Heterogeneity analysis in additional organs.

From: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Fig. 8

a UMAP visualization of the combined analysis of the heart, skeletal muscle, colon, and bladder together with the mesenchymal cells of the brain and lung datasets11, color coded for pagoda2 clusters (upper left) or the organ of origin (upper right). Cell clouds containing mural cells and core SMC are indicated (lower panel). b UMAP visualization highlighting cells of pagoda2 cluster 10 (upper left), cells of the lung VSMC cluster (upper middle), cells of the original complete dataset cluster 14 (upper right), or expression levels of cluster 10 of the combined analysis enriched genes (Nov, Actc1, Eln, and Actg2) as well as Acta2 (gray, low; red, high). c Expression heat map (blue, low; yellow, high) of enriched genes in cluster 10 of the combined analysis (see also Online Supplementary Data 10). d Expression heat map (blue, low; yellow, high) of each 50 most differentially expressed genes in heart vs. brain pericytes (see also Online Supplementary Data 11).

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