Table 1 Germline variants of CMT in DNA damage-repair pathways.

From: Cross-species oncogenic signatures of breast cancer in canine mammary tumors

FunctionGenesP valueGenes with predisposing germline variants
Homology-dependent recombination (HDR)880.029BRCA1, BRCA2, NBN, NSMCE1, POLD1, RECQL4, RMI1, RTEL1, SLX4, SMC5, TOP3B, XRCC3
Fanconi anemia (FA)410.081BRCA1, BRCA2, FAN1, RMI1, SLX4, TOP3B
Direct repair (DR)40.266MGMT
Non-homologous end joining (NHEJ)230.519NBN, RIF1
Mismatch repair (MMR)240.542PMS1, POLD1
Base excision repair (BER)470.689APEX1, NEIL3, POLD1
Translesion synthesis (TLS)200.787POLI
Nucleotide excision repair (NER)510.901ERCC6, POLD1
Nucleotide pools (NP)51.0
  1. The level of significance (P value) was estimated with Fisher’s exact test.