Fig. 5: Cell proliferation of CD4+ and CD8+ T lymphocytes. | Nature Communications

Fig. 5: Cell proliferation of CD4+ and CD8+ T lymphocytes.

From: Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

Fig. 5

a Upper two rows: representative dot plots related to cell proliferation in different types of CD4+ T cells from a control donor (upper panel) and a patient (COVID, lower panel). Lower two rows indicate the proliferation index and the percentage of divided cells in all CD4+ T cells, or in naive, central memory (CM), effector memory (EM), or terminally differentiated (TE) cells. Data represent individual values (dots) from five patients and five controls, mean (centre bar) ± SEM (upper and lower bars). Statistical analysis is performed by two-sided Mann–Whitney nonparametric test; if not indicated, p value is not significant. The gating strategy for the identification of CD4+ T cells is reported in Supplementary Fig. 2. b Upper two rows: representative dot plots related to cell proliferation in different types of CD8+ T cells from a control donor (CTR, upper) and a patient (COVID, lower panel). Lower two rows indicate the proliferation index and the percentage of divided cells in all CD8+ T cells, or in naive, central memory (CM), effector memory (EM), or terminally differentiated (TE) cells. Data represent individual values (dots) from five patients and five controls, mean (centre bar) ± SEM (upper and lower bars). Statistical analysis is performed by two-sided Mann–Whitney nonparametric test; if not indicated, p value is not significant. The gating strategy for the identification of CD8+ T cells is reported in Supplementary Fig. 2.

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