Fig. 1: Overview of new tools immunotherapeutic developments and multiplexed approaches to improve their efficacy. | Nature Communications

Fig. 1: Overview of new tools immunotherapeutic developments and multiplexed approaches to improve their efficacy.

From: Cancer immunotherapy comes of age and looks for maturity

Fig. 1

a Immune checkpoint blockade can be augmented with oncolytic viruses and CAR T cells. b Oncolytic viruses can be engineered to secrete cytokines or combined with engineered T cells. c Advancements in protein engineering have allowed the development of trispecifics, orthogonal cytokine receptor pairs, which allow for selective stimulation of these engineered T cells. d Genome engineering has produced CAR-Ms and genome editing with CRISPR allow for multiple editing of multiple genes in T cells.

Back to article page