Fig. 6: Proposed model for the early events driving adhesiogenesis. | Nature Communications

Fig. 6: Proposed model for the early events driving adhesiogenesis.

From: Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Fig. 6

a Injury to a serosal layer induces a dramatic and rapid shift in mesothelial morphology through the formation of cytoskeletal protrusions. These allow for (1) the physical binding and fusion to neighbouring healthy cells (e.g., at apposing serosal surfaces), and (2) transmission of pathological behavior. This initiates organ tethering and rapid spread of adhesions through serosal surfaces. Once established, mesothelia commit EMT and deposit matrix to form a macroscopic scar.

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