Fig. 5: Correlation between APOBEC3A expression and RNA editing activity in a panel of cancer cell lines. | Nature Communications

Fig. 5: Correlation between APOBEC3A expression and RNA editing activity in a panel of cancer cell lines.

From: Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

Fig. 5

a Analysis of A3A and A3B mRNA expression in a panel of cancer cell lines determined by RT-qPCR. Error bar: S.D. (n = 2). b Quantification of DDOST558C>U and CYFIP13222C>U levels in BICR6 cells by ddPCR assay after A3A knowndown. Error bar: S.D. (n ≥ 3). c Quantification of edited DDOST558C>T and CYFIP13222C>T by ddPCR assay. Error bar: S.D. (n = 3). (*p = 0.0352 for DDOST and p = 0.0111 for CYFIP1 by two-tailed t-test) Source data are provided as a Source Data file.

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