Fig. 3: Analysis of cytoskeletal alterations using virtual fluidic channels. | Nature Communications

Fig. 3: Analysis of cytoskeletal alterations using virtual fluidic channels.

From: High-throughput cell and spheroid mechanics in virtual fluidic channels

Fig. 3

Statistical analysis using linear mixed models of three independent biological replicates for cell deformation (left), cell size (center) and Young’s modulus (right) inside a 20 µm × 20 µm PDMS chip (red) and 21 µm virtual fluidic channel inside a 30 µm × 30 µm PDMS chip (blue). Data compares control cells (n = 8024; PDMS and n = 4040; virtual channel), vehicle control (n = 8948; PDMS and n = 2778; virtual channel) as well as cells after treatment with 1 µM CytoD (n = 4148; PDMS and n = 1237; virtual channel). Data are presented as mean ± standard error of the mean (*p < 0.05; **p < 0.01; and ***p < 0.001).

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