Region-specific change in cerebral blood flow in response to intranasal insulin administration was extracted for the hypothalamus as region of interest (a). Participants with a strong insulin-induced suppression in hypothalamic blood flow had significantly less visceral adipose tissue (b). Subcutaneous fat content was not associated with insulin sensitivity of the hypothalamus (c). The ratio of visceral to subcutaneous adipose tissue was favorably lower in those with strong insulin-induced hypothalamic blood flow (d). Pink filled circles are female participants (N = 53), open blue circles are males (N = 59). Lines represent fit lines ±CI. p values are from unadjusted linear regression models. Source data are provided as a Source Data file.