(a) Changes in body weight; (b) changes in visceral adipose tissue (VAT); (c) changes in subcutaneous adipose tissue (SCAT). Brain insulin sensitivity was assessed as change in the theta frequency band in response to insulin infusion, corrected for saline infusion by magnetoencephalography. p values are from MANOVAs with brain insulin responsiveness as a continuous variable (brain insulin sensitivity × time). N = 15 (a), N = 12 (b, c); presented are means, error bars represent SEM. Filled boxes represent participants with brain insulin responsiveness below the median, open circles represent participants with brain responsiveness above the median. Continuous variables were used for statistical analyses and stratified variables were used solely for better illustration of the results. Source data are provided as a Source Data file.