Fig. 7: Improved reversal learning in Kv4.2TA relative to WT mice. | Nature Communications

Fig. 7: Improved reversal learning in Kv4.2TA relative to WT mice.

From: Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility

Fig. 7

a–c Kv4.2TA mice showed normal learning of the initial platform location in the Morris water maze task. Average escape latencies of four trials per round for WT (n = 16 mice) and Kv4.2TA mice (n = 14 mice) over a training period of 3 days (two rounds each day). b Swimming time heat maps during the probe trial of the WT and Kv4.2TA mice at day 5. c Time spent in each quadrant during the probe trial. df Kv4.2TA mice showed improved reversal learning in the Morris water maze. d Average escape latencies of four trials per round for WT and Kv4.2TA mice over a reversal training period of 2 days (two rounds each day). e Swimming time heat maps during the reversal probe trial of the WT and Kv4.2TA mice at day 8. f Time spent in each quadrant during the reversal probe trial. Two-way ANOVA, *p < 0.05. gi Kv4.2TA mice displayed improved lever press reversal learning. g Number of trainings to reach criteria in initial learning. h Number of active lever press in the 1st day of reversal learning. n = 10 for WT, n = 11 for Kv4.2TA. Two-way ANOVA, *p < 0.05. i Number of active lever press in the 2nd day of reversal learning. n = 10 for WT, n = 11 for Kv4.2TA. Two-way ANOVA, *p < 0.05. Data are presented as mean ± SEM.

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