Fig. 1: Cyclic hexaadenylate recognition by EiCsm6. | Nature Communications

Fig. 1: Cyclic hexaadenylate recognition by EiCsm6.

From: Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Fig. 1

a, b Overall structure of EiCsm6 homodimer bound to cFA6, shown in two orientations (a: side view of the EiCsm6 homodimer; b: view of the cFA6 binding site at the CARF domain interface). The EiCsm6 homodimer is shown in cartoon representation (with protomers colored light and dark blue). cFA6 is depicted in sphere format. c Zoom-in view of the cA6 binding site at the CARF domain interface of EiCsm6, showing a 2mFO–DFC composite omit map, contoured at 1.0 σ and displayed within a radius of 2.2 Å around cFA6.

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