The incorporation of supramolecular macrocycles into porous organic polymers may endow the material with enhanced uptake of specific guests through host−guest interactions. Here we report a solvent and catalyst-free mechanochemical synthesis of pillarquinone (P5Q) derived multi-microporous organic polymers with hydrophenazine linkages (MHP-P5Q), which show a unique 3-step N2 adsorption isotherm. In comparison with analogous microporous hydrophenazine-linked organic polymers (MHPs) obtained using simple twofold benzoquinones, MHP-P5Q is demonstrated to have a superior performance in radioactive iodomethane (CH3I) capture and storage. Mechanistic studies show that the rigid pillararene cavity has additional binding sites though host−guest interactions as well as the halogen bond (−I⋯N = C−) and chemical adsorption in the multi-microporous MHP-P5Q mainly account for the rapid and high-capacity adsorption and long-term storage of CH3I.
Supramolecular macrocycles including crown ethers, cyclodextrins, calixarenes, cucurbiturils, and pillararenes have been known as a kind of supramolecular receptors with intrinsic cavities to bind specific guest molecules in solution1,2,3,4,5,6. Other than the solution-based host–guest chemistry, some supramolecular macrocycles such as calixarenes7 and pillararenes8 exhibit intrinsic microporosity in the solid state for guest adsorption owing to their pre-fabricated cavities of a certain type. Particular attention should be paid to the recent advances in pillararene-based nonporous adaptive crystals (NACs)9,10,11,12,13. Specific guests will trigger the structural change of these nonporous crystals, thus recovering the intrinsic cavities of pillararenes to accommodate guests. This unique property makes NACs of pillararenes promising adsorptive materials in highly selective separations and environment treatment9,10,11,12,13. However, the practical applications of pillararene NACs in these aspects suffer from some inherent shortcomings, such as the slow adsorption rate due to the slow guest-induced structural change process and the limited adsorption amount in the intrinsic cavity.
Porous organic polymers (POPs) are a class of porous materials featuring high surface areas, low densities, synthetic diversity, high chemical/thermal stabilities, etc.14,15,16,17. In light of these unique merits, a variety of POPs including conjugated microporous polymers (CMPs)18,19,20, polymers of intrinsic microporosity21,22, porous aromatic frameworks23,24, microporous hypercrosslinked polymers25,26, covalent triazine frameworks (CTFs)27,28, and covalent organic frameworks (COFs)29,30,31 have been synthesized to explore their full applications in molecular separations, gas storage, catalysis, environmental treatment, and so on. Recently, supramolecular macrocycles have been incorporated into POPs to realize specific applications32,33,34. However, these macrocycles usually act as multi-fold crosslinkers while their pre-fabricated cavities have rarely been demonstrated in POPs presumably due to their flexible skeletons (the cavity is not permanent) or monomer penetration into the cavity. We proposed that the incorporation of pillararene backbones with the reservation of their cavities into POPs might overcome the shortcomings of NACs and combines the properties and advantages of NACs and POPs. Specifically, such material might generate multiple binding sites (intrinsic pillararene cavity for host–guest interactions and extrinsic functional binding sites) for the maximization of specific guest-loading as well as abundant multi-micropores (intrinsic and extrinsic space) for rapid guest transportation by avoiding slow structural transitions.
To this end, we aimed to prepare a POP derived from pillarquinone (P5Q) with a pre-fabricated cavity, through a facile aza-ring formation reaction between ortho-diamines and the repeating benzoquinone units of P5Q35. However, the poor solubility of P5Q in common organic solvents greatly restricts the solution-based synthesis of P5Q-derived POPs. Particular attention was thus paid to mechanochemistry, which has been demonstrated to be a powerful tool in the synthesis of porous materials including metal-organic frameworks, zeolitic imidazolate frameworks and POPs as well36,37,38,39,40,41. Compared with solution-based synthetic procedures in the presence of high-performance catalysts, the solvent-free mechanochemical approach shows superiority in rapid, scalable, and environmentally friendly preparation regardless of the solubility of the monomers. Herein, we report a solvent and catalyst-free mechanochemical synthesis of P5Q-derived multi-microporous organic polymers with hydrophenazine linkages (MHP-P5Q), which displays a unique three-step N2 sorption isotherm with three distinct pore size distribution. In specific, triptycenehexamine (THA) with a unique internal free volume feature is employed as a threefold crosslinker to react with P5Q, a 10-fold monomer, to afford MHP-P5Q. In contrast to analogous microporous hydrophenazine-linked organic polymers (MHPs) obtained using simple benzoquinones (twofold monomers) and THA, MHP-P5Q with similar Brunauer–Emmett–Teller (BET) surface area has a superior performance in the capture and storage of CH3I, a typical radioactive organic iodide waste produced in the nuclear industry. Mechanistic studies confirm that the rigid pillararene cavity as additional binding sites through host–guest interactions as well as the halogen bond (–I∙∙∙N=C–) and chemical adsorption in the multi-microporous MHP-P5Q play a vital role in the rapid and high-capacity adsorption and long-term storage of CH3I.
Mechanochemical synthesis of model compound and MHPs
We firstly investigated the possibility to synthesize an aza-fused hydrophenazine-like model compound (MC) using o-phenylenediamine (o-PDA) and benzoquinone (BQ) via mechanochemistry. Ball milling of o-PDA with BQ for 30 min afforded rigid MC with a yield of over 95% (Supplementary Figs. 4–7), which may be effective for the mechanochemical synthesis of MHPs. Afterward, hydrophenazine-linked microporous organic polymers MHP, MHP-Cl, and MHP-Br were prepared by ball milling of THA (threefold monomers) with simple benzoquinones (twofold monomers) including BQ, 2,5-dichloro-1,4-benzoquinone (BQ-Cl), and 2,5-dibromo-1,4-benzoquinone (BQ-Br) for 30 min, respectively (Fig. 1a). To the best of our knowledge, such a hydrophenazine formation reaction has never been realized via a mechanochemical approach34, let alone in the mechanochemical synthesis of porous polymers. Based on the above, P5Q-derived hydrophenazine-linked microporous organic polymer (MHP-P5Q) was synthesized via the same mechanochemical approach by the substitution of twofold BQs with 10-fold P5Q (Fig. 1b).
Physiochemical characterization of MHPs
The structures of these insoluble polymeric solids were firstly characterized by solid-state 13C cross-polarization magic-angle spinning nuclear magnetic resonance (13C CP-MAS NMR). The 13C CP-MAS NMR spectrum of MHP-P5Q reveals nine carbon peaks with chemical shifts of 201.9, 171.9, 140.7, 129.4, 121.9, 111.9, 81.4, 62.5, and 53.1 ppm, which are assigned to the edge carbonyl (C=O) groups (a), the aromatic (sp2) carbons (b, c, d, e, f, g), and the sp3 bridge carbon (h, i), respectively (Fig. 2a). It is worth noting that the other three samples have identical spectra, which are also similar to that of MHP-P5Q (Supplementary Figs. 8, 11 and 14). An exception for MHP-P5Q is the peak at 62.5 ppm (methylene-bridged carbon on P5Q), which does not exist in the spectra of the other three samples (Fig. 2a). Elemental analysis reveals a nitrogen content of 15.93, 16.25, 13.18, and 10.44 wt% for MHP-P5Q, MHP, MHP-Cl, and MHP-Br, respectively, indicating the existence of abundant nitric groups in MHPs. X-ray photoelectron spectroscopy (XPS) was performed to probe the nitrogen bonding nature in MHPs. The spectrum of MHP-P5Q shows two N 1s peaks at 398.88 and 400.48 eV, which can be attributed to the characteristic imine nitrogen atoms and aniline nitrogen atoms42, respectively (Fig. 2b). Meanwhile, the two peak areas are almost the same, indicating the identical content of the two nitrogen species in MHP-P5Q. Similar results are also observed for MHP, MHP-Cl, and MHP-Br (Supplementary Fig. 18), revealing the formation of hydrophenazine rings in MHPs. Fourier-transform infrared spectroscopy (FT-IR) showed that MHP-P5Q and MHP have several similar peaks at 1713/1712, 1624/1614, and 1356/1351 cm−1, corresponding to the stretching vibrations of C=O, C=N, and C–N, respectively (Fig. 2c). Such characteristic peaks can also be found in the spectra of MHP-Cl and MHP-Br (Supplementary Fig. 19). These results are thus consistent with XPS and 13C CP-MAS NMR results. The thermal stability of MHPs was determined by thermogravimetric analysis (TGA). All four MHPs were demonstrated to be stable below around 330 °C, indicating their good thermal stability (Supplementary Figs. 10, 13, 16, and 21).
Powder X-ray diffraction (PXRD) experiments were performed to investigate the long-range ordering of MHPs. No sharp peaks were observed in the PXRD spectra for all MHPs, revealing their amorphous nature (Supplementary Figs. 9, 12, 15, and 20). Meanwhile, the bulk morphologies of MHP-P5Q were visualized with field-emission scanning electron microscopy (FE-SEM). The SEM images show that MHP-P5Q consists of relatively uniform solid sub-micron spheres (Fig. 2d, e). These fused polymer masses without well-defined shapes also imply the loss of long-range order. The internal structure of MHP-P5Q was visualized by high-resolution transmission electron microscopy (HR-TEM). No ordered structures or crystal lattice can be observed at the nanoscale, indicating the loss of crystallinity (Fig. 2f).
Gas sorption studies
Nitrogen sorption experiments at 77 K were then carried out to evaluate the porosity of MHPs. As shown in Fig. 3a, MHP, MHP-Cl, and MHP-Br display typical type I sorption isotherms, indicating the microporosity of the three materials. Intriguingly, a unique adsorption isotherm with three distinct steps can be observed for MHP-P5Q (Fig. 3b), which is often characteristic of porous materials with a uniform distribution of different pore sizes43. As far as we know, this phenomenon has barely been observed in amorphous porous polymers. The BET surface areas of MHP, MHP-Cl, MHP-Br, and MHP-P5Q are calculated to be 320, 289, 208, and 296 m2/g, respectively, whereas their calculated total pore volumes are 0.16, 0.14, 0.11, and 0.13 cm3/g, respectively. The pore size distributions of MHP, MHP-Cl, and MHP-Br determined by NLDFT all showed multiple peaks ranging from 0.7 to 2.0 nm, indicating the nonuniform pore size distribution (Supplementary Figs. 22−24). In contrast, the pore size distribution of MHP-P5Q showed three distinct peaks with pore diameters at 0.76, 1.19, and 1.30 nm, respectively, implying the uniform multi-microporosity (Fig. 3b). It is worth noting that the pore diameter at 0.76 nm is consistent with the cavity size of pillararene44, which on the other hand confirms the presence of the permanent pillararene cavity in the robust frameworks. Meanwhile, all the MHPs show abundant microporosity as the ratio of micropore volume to the total pore volume (Vmicro/Vtotal) is assessed to be 0.69, 0.75, 0.73, and 0.77 for MHP, MHP-Cl, MHP-Br, and MHP-P5Q, respectively (Supplementary Table 2).
To better understand the formation mechanism of the multi-microporous structure of MHP-P5Q, samples of P5Q-TAB and P5Q-DAB were obtained using twofold diamines including 1,2,4,5-tetraaminobenzene (TAB) and 3,3′-diaminobenzidine (DAB) with P5Q via mechanochemistry. However, the two samples were demonstrated to be barely porous (Supplementary Fig. 25), indicating that the threefold THA also played a vital role in the construction of multi-microporous polymer MHP-P5Q. On the one hand, the reaction between P5Q and threefold THA endows MHP-P5Q with 3D framework structures, thus generating extrinsic microporosity. On the other hand, THA with a huge fragment can avoid monomer penetration into P5Q cavity and inhibit the rotation of the P5Q repeating units as well, thus leading to the preservation of intrinsic P5Q cavities in the 3D framework. In contrast, the reactions of linear twofold diamines with P5Q are likely to form linear polymers, resulting in the loss of porosity.
After evaluation of the porosity, the CO2 adsorption capabilities of MHPs were also investigated. The CO2 uptake amount at 1 bar and 273 K for MHP, MHP-Cl, MHP-Br, and MHP-P5Q are 2.37, 2.14, 2.09, and 2.63 mmol/g, respectively, while those at 1 bar and 298 K are 1.77, 1.75, 1.68, and 2.09 mmol/g, respectively (Fig. 3c, d). The results reveal that although the BET surface area of MHP-P5Q is lower than MHP, it has the best CO2 capture performance among the four MHPs. This may be ascribed to the synergistic effects of the multi-microporosity in MHP-P5Q for CO2 transportation and the abundant CO2-philic surface sites, including unreacted C=O sites and nitric sites45.
Radioactive organic iodide capture performance
Nuclear energy has been growing rapidly to meet the increasing demand for global energy. One challenge to be faced with is the capture and reliable storage of nuclear waste including radioactive molecular iodine (I2) and organic iodides (e.g., iodomethane and iodoethane) in the production to ensure safe nuclear energy usage46,47. The capture of radioactive organic iodides is particularly challenging due to their high volatility46,47,48,49,50. We envisioned that MHP-P5Q with abundant nitric groups and multi-micropore structures might be an ideal adsorbent to capture and store radioactive organic iodides. Other MHPs as well as perethylated pillararene (EtP5) crystals (Supplementary Fig. 35), a kind of well-investigated NACs, were also investigated as contrasts.
To explore the adsorption capacities in these adsorbents, iodomethane (CH3I) vapor sorption isotherms of MHPs were firstly obtained. As can be seen from Fig. 4a, the CH3I vapor adsorption amount in MHP-P5Q is the highest (218 cm3/g) at 1 bar and 298 K, while those in MHP, MHP-Cl, MHP-Br, and EtP5 are significantly lower with the values of 143, 110, 102.5, and 55 cm3/g, respectively. In specific, the uptake of CH3I in EtP5 shows a typical gate-opening behavior with the gate-opening pressure at P/P0 = 0.7 (Fig. 4a, purple squares), which has been observed previously for pillararene NACs in the adsorption of other hydrocarbons9,10,11,12,13. It is notable that distinct hysteresis in the desorption process can be observed for all five adsorbents, indicating the strong interactions between CH3I and these adsorbents. Meanwhile, a certain amount of the adsorbed CH3I is retained in the adsorbents even under reduced pressure (Fig. 4a). For MHP-P5Q, the reserved amount is 118 cm3/g, which is about 54% of the absorbed amount (Fig. 4a, b). The reserved amounts for MHP, MHP-Cl, and MHP-Br are 67, 51, and 48 cm3/g, respectively, which are less than half of the adsorbed amount (Fig. 4a, b). For EtP5, the reserved amount is quite small (9 cm3/g), indicating the less stable storage of CH3I (Fig. 4a, b). The above results imply that MHP-P5Q has the highest CH3I capture capacity and the potential in the storage of the captured CH3I.
To demonstrate the ability of these adsorbents in the capture of CH3I from the air, time-dependent solid–vapor adsorption experiments were then carried out. Similar to the vapor sorption isotherm results, MHP-P5Q was demonstrated to have the highest uptake amount of CH3I (80.3 wt%), followed by MHP (62.2 wt%), MHP-Cl (52.8 wt%), MHP-Br (49.2 wt%), and EtP5 (27.6 wt%; Fig. 4c). Meanwhile, the uptake rate of CH3I in MHP-P5Q is also the highest among these adsorbents. It took only 1 h for MHP-P5Q to reach the saturation point while the time for other MHPs was 2 h (Fig. 4c). A longer time (6 h) was needed for EtP5 to reach the saturation point, a typical phenomenon for these nonporous crystals due to the slow structural transformations (Fig. 4c). We also compared the CH3I adsorption capacities of MHPs with several benchmark adsorbents that are actually used in nuclear industry, such as activated porous carbon impregnated with triethylenediamine (TED@AC) and silver functionalized zeolites (including ZSM-5, 13×, and mordenite, which are named as Ag+@ZSM-5, Ag+@13×, Ag+@MOR, and Ag0@MOR for short, respectively, Supplementary Fig. 27). The results confirm that MHP-P5Q has the best performance in CH3I capture from air, which may be beneficial for its potential use in nuclear energy production.
Another practical task for adsorbent is the reliable storage of the radioactive organic iodides after they are captured from nuclear wastes. Leakage of these radioactive species from the adsorbents may severely damage not only the staff in the nuclear energy industry but also the surrounding residents and environment40. In order to demonstrate the long-term storage of CH3I in these adsorbents, the CH3I-loaded samples were exposed to the atmosphere for 30 days at room temperature. Gravimetric analyses showed that the reserved amount of CH3I in MHP-P5Q was 77.6 wt%, meaning that more than 97% of the adsorbed CH3I was stably stored in MHP-P5Q (Fig. 4d). In contrast, the reserved CH3I percentage in MHP, MHP-Cl, and MHP-Br is 86.7%, 81.4%, and 75.2%, respectively, while that in EtP5 is only 25.4% (Fig. 4d). The above experimental results suggest that the captured CH3I can be stored in MHP-P5Q with exceptional long-term stability, which remarkably exceeds other adsorbents.
The exceptional CH3I capture performance and particularly stable CH3I storage in MHP-P5Q prompted us to investigate the possible mechanism. Hence, the structures of CH3I-loaded MHP-P5Q (CH3I@MHP-P5Q) as well as CH3I-loaded MHP (CH3I@MHP) were characterized by solid-state TGA, XPS, and FT-IR experiments. Surprisingly, N 1s XPS spectra of both CH3I@MHP-P5Q and CH3I@MHP show three distinct peaks, which are distinctly different from pristine MHP-P5Q and MHP (Fig. 5a, b). The peaks corresponding to the nitrogen atoms on the imine group remain the same while the peaks related to the nitrogen atoms on the aniline group are split to two peaks with the smaller one remaining at the same position and the larger one red shifting to 401.48 eV. This shift indicates that the state of N on the aniline groups changes through the interactions with CH3I molecules. FT-IR spectra of CH3I@MHP-P5Q and CH3I@MHP display several new peaks at 982 and 1071 cm−1 (Fig. 5c, d), implying the formation of new C–N bonds in these two materials. TGA results show that the weight loss below 100 °C are 7 and 10 wt% for CH3I@MHP and CH3I@MHP-P5Q, respectively, indicating that only a small fraction of the captured CH3I was released at the temperature higher than its boiling point (Supplementary Fig. 29). Elemental mapping using HR-TEM energy-dispersive X-ray spectroscopy (HR-TEM-EDS) confirms that after heating CH3I@MHP and CH3I@MHP-P5Q at 100 °C for 2 h, iodine (CH3I) are still found to be uniformly dispersed within the two porous polymer samples (Fig. 5e, f). According to the above results, we deduced that not only physical adsorption but also chemical adsorption of CH3I occurred in these two adsorbents and the chemical adsorption site might be the aniline nitrogen atoms on the hydrophenazine rings.
To confirm the possible chemical adsorption process and probe the chemical adsorption site, CH3I-appended MC (MC-CH3I) was firstly obtained in a solution-based reaction. 1H NMR spectrum of MC-CH3I clearly shows the proton signals of the methyl group, confirming the strong attachment of CH3I onto MC (Supplementary Figs. 30 and 31). To further illustrate the chemical adsorption site, CH3I-appended MHP-P5Q (MHP-P5Q-CH3I) and MHP (MHP-CH3I) were synthesized through solution-based post-synthetic modifications of MHP-P5Q and MHP, respectively (Fig. 6a). Compared with MHP-P5Q and MHP, the 13C CP-MAS NMR spectra of the resulting MHP-P5Q-CH3I and MHP-CH3I show two new sharp peaks at around 36 ppm, which are corresponding to the carbons on the methyl group (Supplementary Figs. 32 and 33). Elemental analysis reveals an iodine content of 34.13 and 30.15 wt% for MHP-P5Q-CH3I and MHP-CH3I, respectively. These results confirm the successful graft of CH3I onto MHP-P5Q and MHP. Meanwhile, the N 1s XPS spectrum of MHP-P5Q-CH3I show two peaks at 399.08 and 401.28 eV, with the former corresponding to imine nitrogen atoms and the latter referring to the aniline nitrogen atoms after attachment of CH3I (Fig. 5a). The FT-IR spectra of MHP-P5Q-CH3I and CH3I@MHP-P5Q are quite similar but different from the pristine MHP-P5Q (Fig. 5c). According to the above results, we can conclude that a large number of aniline groups on MHP-P5Q took part in the chemical adsorption of CH3I while only a small amount of aniline groups remained unreactive. In contrast, the N 1s XPS spectra of both MHP-CH3I and CH3I@MHP show three peaks at 399.08, 400.18, and 401.28 eV, indicating that the reaction of CH3I with MHP in solution was incomplete and the chemical adsorption of CH3I occurred on the aniline group of MHP (Fig. 5b). The similarity in the FT-IR spectra of MHP-CH3I and CH3I@MHP further confirmed the above result (Fig. 5d).
Gas adsorption experiments of MHP-P5Q-CH3I and MHP-CH3I were further carried out to demonstrate their porosity. N2 sorption experiments revealed Type I sorption isotherms for MHP-P5Q-CH3I and MHP-CH3I with their BET surface areas of 98 and 110 m2/g, respectively, which are significantly lower than the pristine MHP-P5Q and MHP (Fig. 6b). Meanwhile, the three-step N2 adsorption isotherm cannot be observed for MHP-P5Q-CH3I. The results suggest that the attachment of CH3I has a huge effect on the pore structure of MHP-P5Q and MHP, resulting in a decrease of their porosity. Moreover, the CH3I capture capacity of MHP-P5Q-CH3I and MHP-CH3I were demonstrated to have a huge decrease. The maximum capacity for MHP-P5Q-CH3I is 42.5 wt% whereas that of MHP-CH3I is 35.2 wt% (Fig. 6c). It is thus implied that the chemical adsorption process played a vital role in the CH3I capture.
In addition to the chemical adsorption, the physical adsorption of CH3I in MHP-P5Q and MHP is also significant. To demonstrate the potential physical-binding site for MHP-P5Q and MHP, quantum chemical calculations were carried out using the MP2 method. Two molecules, 1,2-dihydrophenazine with –C=N– bond and 5,10-dihydrophenazine without the double bond, were chosen as MCs. The calculation results show that CH3I forms the weak halogen bond with –N=C– in 1,2-dihydrophenazine with d[N∙∙∙I] = 3.39 Å while such a halogen bond does not occur in 5,10-dihydrophenazine, whose binding energy with CH3I is even smaller (Supplementary Fig. 34). Based on these results, one of the potential physical-binding sites for CH3I in MHP-P5Q and MHP may be the imine group on the hydrophenazine rings through halogen bonding (–I∙∙∙N=C–).
Given the fact that the amine and imine groups as chemical adsorption sites and physical-binding sites exist in both MHP-P5Q and MHP, we deduced that the enhanced CH3I adsorption capacity in MHP-P5Q might also benefit from the pillararene skeletons embedded in the framework, which offer additional binding sites for CH3I. To better understand the affinity between CH3I and pillararene backbone, EtP5 without other functional groups was also chosen as a model (Supplementary Fig. 35). Single-crystal X-ray diffraction structure of CH3I-loaded EtP5 (CH3I@EtP5) shows that CH3I forms a 1:2 host–guest inclusion complex with EtP5 with their methyl groups in the cavity center while no CH3I molecules can be found in the extrinsic space of EtP5 (Fig. 7). The hydrogen atoms on the methyl groups are found to have CH∙∙∙π interactions with corresponding nearest arenes on EtP5. Hence, multiple CH∙∙∙π interactions are the main driving force for the formation of the inclusion complex. Moreover, the PXRD pattern of EtP5 after adsorption of CH3I matches well with that simulated from CH3I@EtP5, indicating that EtP5 transform to CH3I@EtP5 upon capture of CH3I (Supplementary Fig. 34). Thus, the limited CH3I adsorption amount in EtP5 can be attributed to the limited accessible intrinsic cavity for CH3I, whereas the extrinsic space cannot be utilized for CH3I loading. However, these multiple CH∙∙∙π interactions alone are not strong enough for the long-term storage of CH3I in EtP5. Based on above, we can conclude that compared with other MHPs, the presence of pillararene cavity in MHP-P5Q offers additional binding sites for CH3I through host–guest interactions (multiple CH∙∙∙π interactions), thus enhancing the adsorption capacity. In contrast to EtP5, the enhanced adsorption capacity of CH3I in MHP-P5Q benefits from the abundant nitric groups in the multi-microporous framework for offering the halogen bond (–I∙∙∙N=C–) as well as chemical adsorption sites. The synergistic effect of the multiple supramolecular interactions and the formation of chemical bonds in the unique multi-microporous structure contribute to the superior performance of MHP-P5Q in CH3I capture and storage.
In conclusion, we reported a solvent and catalyst-free mechanochemical synthesis of P5Q-derived hydrophenazine-linked multi-microporous organic polymer MHP-P5Q regardless of the poor solubility of P5Q. Benefitting from our rational design and the unique synthesis, MHP-P5Q displays a unique three-step N2 sorption isotherm with three distinct pore size distribution. Compared with MHP, MHP-Cl, and MHP-Br, MHP-P5Q with similar BET surface area was demonstrated to have a superior performance in the capture and storage of CH3I, a typical radioactive organic iodide waste in the nuclear industry. Mechanistic studies confirm that the rapid and high-capacity adsorption and stable storage of CH3I in MHP-P5Q come from the rigid pillararene cavity as additional binding sites for CH3I through CH∙∙∙π interactions as well as halogen bond (–I∙∙∙N=C–) between CH3I and imine group and chemical adsorption in the multi-microporous framework. Hence, MHP-P5Q as an adsorbent can interact with both the polar part (∙∙∙I) and nonpolar part (∙∙∙CH3) of CH3I through a synergistic effect to achieve the maximization in CH3I capture and storage, which is superior to other adsorbents that only have single interactions with either the polar or the nonpolar part of CH3I. A future challenge may be targeted to the incorporation of other supramolecular macrocycles with the reservation of their cavities into robust porous frameworks for task-specific applications.
Synthesis of MHP
Benzoquinone (0.108 g; 1 mmol) and triptycenehexaamine hexahydrochloride (0.374 g; 0.67 mmol) were added into a 15 mL stainless steel grinding jar (33 mm diameter) with three steel balls. The mixture was then ground for 30 min in a Retsch MM400 grinder mill operating at 30 Hz. The solids were washed with saturated NaHCO3 solution for two times and methanol for four times, which were dried at 100 °C for 12 h to give dark brown powders (0.148 g).
Synthesis of MHP-Cl
The synthesis of MHP-Cl is pretty similar to that of MHP. In particular, 2,5-dichloro-1,4-benzoquinone (0.176 g; 1 mmol) and triptycenehexaamine hexahydrochloride (0.374 g; 0.67 mmol) were added into a 15-mL stainless steel grinding jar (33 mm diameter) with three steel balls. The mixture was then ground for 30 min in a Retsch MM400 grinder mill operating at 30 Hz. The solids were washed with saturated NaHCO3 solution for two times and methanol for four times, which were dried at 100 °C for 12 h to give dark brown powders (0.218 g).
Synthesis of MHP-Br
The synthesis of MHP-Br is pretty similar to that of MHP. In particular, 2,5-dibromo-1,4-benzoquinone (0.265 g; 1 mmol) and triptycenehexaamine hexahydrochloride (0.374 g; 0.67 mmol) were added into a 15-mL stainless steel grinding jar (33 mm diameter) with three steel balls. The mixture was then ground for 30 min in a Retsch MM400 grinder mill operating at 30 Hz. The solids were washed with saturated NaHCO3 solution for two times and methanol for four times, which were dried at 100 °C for 12 h to give dark brown powders (0.276 g).
Synthesis of MHP-P5Q
The synthesis of MHP-P5Q is pretty similar to that of MHP. In particular, P5Q (0.150 g; 0.25 mmol) and triptycenehexaamine hexahydrochloride (0.468 g; 0.838 mmol) were added into a 15-mL stainless steel grinding jar (33 mm diameter) with three steel balls. The mixture was then ground for 30 min in a Retsch MM400 grinder mill operating at 30 Hz. The solids were washed with saturated NaHCO3 solution for two times and methanol for four times, which were dried at 100 °C for 12 h to give dark brown powders (0.204 g).
The X-ray crystallographic coordinates for structures reported in this study have been deposited at the Cambridge Crystallographic Data Centre (CCDC), under deposition number 1948606. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif. All other data supporting the findings of this study are available from the article and its Supplementary Information files or available from the corresponding authors upon reasonable request.
Gokel, G. W., Leevy, W. M. & Weber, M. E. Crown ethers: sensors for ions and molecular scaffolds for materials and biological models. Chem. Rev. 104, 2723–2750 (2004).
Li, S. & Purdy, W. C. Cyclodextrins and their applications in analytical chemistry. Chem. Rev. 92, 1457–1470 (1992).
Ikeda, A. & Shinkai, S. Novel cavity design using Calix[n]arene skeletons: toward molecular recognition and metal binding. Chem. Rev. 97, 1713–1734 (1997).
Isaacs, L. Stimuli responsive systems constructed using cucurbit[n]uril-type molecular containers. Acc. Chem. Res. 47, 2052–2062 (2014).
Ogoshi, T., Yamagishi, T. & Nakamoto, Y. Pillar-shaped macrocyclic hosts pillar[n]arenes: new key players for supramolecular chemistry. Chem. Rev. 116, 7937–8002 (2016).
Dsouza, R. N., Pischel, U. & Nau, W. M. Fluorescent dyes and their supramolecular host/guest complexes with macrocycles in aqueous solution. Chem. Rev. 111, 7941–7980 (2011).
Holst, J. R., Trewin, A. & Cooper, A. I. Porous organic molecules. Nat. Chem. 2, 915–920 (2010).
Song, N., Kakuta, T., Yamagishi, T., Yang, Y.-W. & Ogoshi, T. Molecular-scale porous materials based on pillar[n]arenes. Chem 4, 2029–2053 (2018).
Jie, K., Zhou, Y., Li, E. & Huang, F. Nonporous adaptive crystals of pillararenes. Acc. Chem. Res. 51, 2064–2072 (2018).
Jie, K. et al. Styrene purification by guest-induced restructuring of pillararene. J. Am. Chem. Soc. 139, 2908–2911 (2017).
Li, E., Jie, K., Zhou, Y., Zhao, R. & Huang, F. Post-synthetic modification of nonporous adaptive crystals of pillararenequinone by capturing vaporized amines. J. Am. Chem. Soc. 140, 15070–15079 (2018).
Jie, K. et al. Near-ideal xylene selectivity in adaptive molecular pillar[n]arene crystals. J. Am. Chem. Soc. 140, 6921–6930 (2018).
Jie, K., Zhou, Y., Li, E., Zhao, R. & Huang, F. Separation of aromatics/cyclic aliphatics by nonporous adaptive pillararene crystals. Angew. Chem. Int. Ed. 57, 12845–12849 (2018).
Das, S., Heasman, P., Ben, T. & Qiu, S. Porous organic materials: strategic design and structure–function correlation. Chem. Rev. 117, 1515–1563 (2017).
Wu, J. et al. Porous polymers as multifunctional material platforms toward task-specific applications. Adv. Mater. 30, 1802922 (2018).
Zou, L. et al. Porous organic polymers for post-combustion carbon capture. Adv. Mater. 29, 1700229 (2017).
Dawson, R., Cooper, A. I. & Adams, D. J. Nanoporous organic polymer networks. Prog. Polym. Sci. 37, 530–563 (2012).
Cooper, A. I. Conjugated microporous polymers. Adv. Mater. 21, 1291–1295 (2009).
Xu, Y., Jin, S., Xu, H., Nagai, A. & Jiang, D. Conjugated microporous polymers: design, synthesis and application. Chem. Soc. Rev. 42, 8012–8031 (2013).
Jiang, J.-X. et al. Conjugated microporous poly (aryleneethynylene) networks. Angew. Chem. Int. Ed. 46, 8574–8578 (2007).
McKeown, N. B. & Budd, P. M. Polymers of intrinsic microporosity (PIMs): organic materials for membrane separations, heterogeneous catalysis and hydrogen storage. Chem. Soc. Rev. 42, 8012–8031 (2013).
Song, Q. et al. Controlled thermal oxidative crosslinking of polymers of intrinsic microporosity towards tunable molecular sieve membranes. Nat. Commun. 5, 4813 (2014).
Ben, T. et al. Gas storage in porous aromatic frameworks (PAFs). Energy Environ. Sci. 4, 3991–3999 (2011).
Ben, T. et al. Targeted synthesis of a porous aromatic framework with high stability and exceptionally high surface area. Angew. Chem. Int. Ed. 48, 9457–9460 (2009).
Luo, Y., Li, B., Wang, W., Wu, K. & Tan, B. Hypercrosslinked aromatic heterocyclic microporous polymers: a new class of highly selective CO2 capturing materials. Adv. Mater. 24, 5703–5707 (2012).
Xu, S., Luo, Y. & Tan, B. Recent development of hypercrosslinked microporous organic polymers. Macromol. Rapid Commun. 34, 471–484 (2013).
Kuhn, P., Antonietti, M. & Thomas, A. Porous, covalent triazine-based frameworks prepared by ionothermal synthesis. Angew. Chem. Int. Ed. 47, 3450–3453 (2008).
Ren, S. et al. Porous, fluorescent, covalent triazine‐based frameworks via room‐temperature and microwave‐assisted synthesis. Adv. Mater. 24, 2357–2361 (2012).
Côté, A. P. et al. Porous, crystalline, covalent organic frameworks. Science 310, 1166–1170 (2005).
Feng, X., Ding, X. & Jiang, D. Covalent organic frameworks. Chem. Soc. Rev. 41, 6010–6022 (2012).
Sun, Q. et al. Postsynthetically modified covalent organic frameworks for efficient and effective mercury removal. J. Am. Chem. Soc. 139, 2786–2793 (2017).
Li, X., Li, Z. & Yang, Y.-W. Tetraphenylethylene-interweaving conjugated macrocycle polymer materials as two-photon fluorescence sensors for metal ions and organic molecules. Adv. Mater. 30, 1800177 (2018).
Alsbaiee, A. et al. Rapid removal of organic micropollutants from water by a porous β-cyclodextrin polymer. Nature 529, 190–194 (2016).
Shetty, D. et al. Porous polycalixarenes for fast and efficient removal of organic micropollutants from water. ACS Appl. Mater. Interfaces 10, 2976–2981 (2018).
Kour, H., Paul, S., Singh, P. P. & Gupta, R. A mild and simple method for the synthesis of substituted phenazines. Synlett 25, 495 (2014).
Xu, W. et al. Entropy-driven mechanochemical synthesis of polymetallic zeolitic imidazolate frameworks for CO2 fixation. Angew. Chem. Int. Ed. 58, 5018–5022 (2019).
Friščić, T. et al. Real-time and in situ monitoring of mechanochemical milling reactions. Nat. Chem. 5, 66 (2013).
James, S. L. et al. Mechanochemistry: opportunities for new and cleaner synthesis. Chem. Soc. Rev. 41, 413–447 (2012).
Zhang, P. & Dai, S. Mechanochemical synthesis of porous organic materials. J. Mater. Chem. A 5, 16118–16127 (2017).
Do, J.-L. & Friščić, T. Mechanochemistry: a force of synthesis. ACS Cent. Sci. 3, 13–19 (2017).
Beldon, P. J. et al. Rapid room-temperature synthesis of zeolitic imidazolate frameworks by using mechanochemistry. Angew. Chem. Int. Ed. 49, 9640–9643 (2010).
Wu, J.-B. et al. Correlation between N 1s XPS binding energy and bond distance in metal amido, imido, and nitrido complexes. Inorg. Chem. 42, 4516–4518 (2003).
Li, P. et al. Bottom-up construction of a superstructure in a porous uranium-organic crystal. Science 356, 624–627 (2017).
Yu, G., Jie, K. & Huang, F. Supramolecular amphiphiles based on host–guest molecular recognition motifs. Chem. Rev. 115, 7240–7303 (2015).
Zhu, X. et al. In situ doping strategy for the preparation of conjugated triazine frameworks displaying efficient CO2 capture performance. J. Am. Chem. Soc. 138, 11497–11500 (2016).
Chapman, K. W., Chupas, P. J. & Nenoff, T. M. Radioactive iodine capture in silver-containing mordenites through nanoscale silver iodide formation. J. Am. Chem. Soc. 132, 8897–8899 (2010).
Li, B. et al. Capture of organic iodides from nuclear waste by metal-organic framework-based molecular traps. Nat. Commun. 8, 485 (2017).
Park, S. W., Park, H. S., Lee, W. K. & Moon, H. Effect of water vapor on adsorption of methyl iodide to triethylenediamine-impregnated activated carbons. Sep. Technol. 5, 35–44 (1995).
González-García, C. M., González, J. F. & Román, S. Removal efficiency of radioactive methyl iodide on teda-impregnated activated carbons. Fuel Process. Technol. 92, 247–252 (2011).
Sun, Q., Aguila, B. & Ma, S. Opportunities of porous organic polymers for radionuclide sequestration. Trends Chem. 1, 292–303 (2019).
This work was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division.
The authors declare no competing interests.
Peer review information Nature Communications thanks T. Jean Daou, Shengqian M and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
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Jie, K., Zhou, Y., Sun, Q. et al. Mechanochemical synthesis of pillarquinone derived multi-microporous organic polymers for radioactive organic iodide capture and storage. Nat Commun 11, 1086 (2020). https://doi.org/10.1038/s41467-020-14892-y