Fig. 2: Single-cell sequencing identifies a distinct cancer stem cell-like and other tumor-specific cell populations. | Nature Communications

Fig. 2: Single-cell sequencing identifies a distinct cancer stem cell-like and other tumor-specific cell populations.

From: Tracing tumorigenesis in a solid tumor model at single-cell resolution

Fig. 2

a Clustering of combined single-cell sequencing data from control and double-mutant (β-catGOF; Bmpr1aLOF) tumor-bearing salivary glands shown in the tSNE. Tumor-specific epithelial cell clusters are shown in the lower right part of the tSNE in shades of pink: cancer stem, basal, luminal Clu+ cells. b Same tSNE plot showing the relative local densities of control and double-mutant cells. Color gradients reveal clusters that are predominantly represented by double-mutant (red), control (blue) or both double-mutant and control cells (gray). c Expression of Axin2, Ptn, Wif1, Clu, and Wfdc18 in the tumor-specific epithelial subset of the tSNE representation as indicated by a color scale ranging from gray (no expression) to maroon (high expression).

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