The first column shows the input, the top image additionally shows a fraction of the labels that were used for training. The second column shows the probability output map of the random forest pixel classifier from ilastik. The third column shows the segmentation result by thresholding the probability maps, and the fourth column the ground truth segmentation (the Dice coefficient is shown in the upper left corner). Noise artifacts are clearly visible in the segmentation and can be avoided by denoising as a pre-processing step. Notice that denoising can even improve the segmentation result.