a Scatterplot of median activity errors (i.e. absolute activity difference) on all depth 30 simulations (see Supplementary Fig. 3 for depths 10 and 100). Mean activity error: TrackSig 3.5%, SciClone 6.2%. b Grouped barplot shows proportion of simulations where each method predicts the correct number of subclones for different simulation types as indicated on x-axis label. Different SciClone bars indicate different noise model selections. Results are for the simulations of average depth 30. Results for depths 10 and 100 are shown in Supplementary Fig. 2.