Fig. 4: Representative images of key features. | Nature Communications

Fig. 4: Representative images of key features.

From: Automated acquisition of explainable knowledge from unannotated histopathology images

Fig. 4

The top 10 images are closest to the centroids of the 100 features, with higher-ranking images being larger, in the biochemical recurrence (BCR) group (aj) and no BCR group (kt). aj Cancers equivalent to Gleason patterns 4 or 5, which usually indicate aggressive clinical behavior. c Dense stromal components without cancer cells. g Hemorrhage. p Cancers equivalent to Gleason pattern 3, which usually indicates benign clinical behavior. koqs Loose stromal components without cancer cells. t Surgical margin without cancer cells. The scale bar included in each image represents a length of 100 μm. Expert genitourinary pathologist’s comments on BCR images (aj): Cancers show Gleason patterns 4 or 5 indicating aggressive clinical behavior. Stromal component without cancer cells tends to show dense cellularity compared to those of normal structure. The pathologist’s comments on no BCR images (kt): Cancers show Gleason pattern 3 indicating indolent clinical behavior. Stromal component without cancer cells tends to show relatively loose cellularity suggesting normal peripheral zone structure. Cauterized extraprostatic connective tissue without cancer cells, which indicate that the surgical margin is free from cancer.

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