Fig. 6: Serum biomarker levels for Abcb4−/− mice treated at 5 weeks of age with AAV-MDR3-Aco. | Nature Communications

Fig. 6: Serum biomarker levels for Abcb4−/− mice treated at 5 weeks of age with AAV-MDR3-Aco.

From: Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Fig. 6

The therapeutic effect of AAV treatment is shown in males (a) and females (b) that were treated with AAV-MDR3-Aco at 1 × 1014 VG/kg one time (1×, red, filled circles; n = 4 M/4 F), using as controls saline-treated (blue, open squares; n = 3 M/4 F) and untreated Abcb4+/+ (WT) mice (black, open circles; n = 3 M/3 F). Data are presented as mean + SD. ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, BS bile salts. Source data are provided as a Source Data file.

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