Fig. 1 | Nature Communications

Fig. 1

From: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Fig. 1

LRV and MCL associate with decreased levels of IL-1β and Casp1 p20. ac Patients were grouped according to the outcome of the disease (CL = Cutaneous Leishmaniasis; MCL = Mucocutaneous Leishmaniasis), regardless of the infecting Leishmania specie. Levels of IL-1β (a) and cleaved Casp1 (b) were quantified by ELISA in aspirates collected from lesions from both CL (n = 40) and MCL (n = 9) patients, and the frequency of LRV+ and LRV− parasites among each group is shown (c). dg The same group of patients was distributed according to their LRV status, regardless of the infecting Leishmania specie. Levels of IL-1β (d), cleaved Casp1 (e), and TNF-α (f) were plotted from both LRV+ (n = 19) and LRV− (n = 30) patients, and the frequency of CL and MCL among each group is shown (g). Each value was corrected to the respective amount of protein (determined by Bradford) from each patient. Statistical analysis was performed by Mann–Whitney’s test. P < 0.05 (*) was considered statistically significant

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