Fig. 4 | Nature Communications

Fig. 4

From: Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Fig. 4

Polymorphism of brain-derived Aβ fibrils. a 300 kV Cryo-EM images of fibril morphologies I−III. Scale bar: 20 nm. b Crossover distance and fibril width values of fibril morphologies I−III (n = 30). Black cross: average value and standard deviation. c Relative abundance of fibril morphologies I−III in our sample. d Cross-sectional densities of fibril morphologies I−III (gray) superimposed with the molecular model obtained with fibril morphology I. e Close-up of the PF−PF interface of fibril morphology II, indicated by a box in panel (d), showing the juxtaposed residues Glu3 and Arg5

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