Fig. 2 | Nature Communications

Fig. 2

From: Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

Fig. 2

Constitutive expression of IL-23 in K14+ cells results in early lethality. a Scheme for generation of KSR23 mice. KSR23 mice were generated by crossing R23 mice with mice expressing cre-recombinase from the K14 promoter (K14-cre mice). b, c Relative expression of p19 (b) and p40 (c) mRNA in several organs of WT and KSR23 mice at P7 (n = 4–13 mice/group). d Body weight of WT and KSR23 mice during the first week of life (n = 14–26 mice/group). e Representative picture of WT and KSR23 mice at P5. f Survival curves of WT and KSR23 mice (WT, n = 54; KSR23, n = 105). g Representative picture of the large intestine of WT and KSR23 mice at day 5. Notice the presence of soft yellow stool in the colon of KSR23 mice. h Quantification of triglycerides in the stool of WT (n = 12) and KSR23 (n = 21) mice at P5. i Quantification of triglycerides in the serum of WT (n = 35) and KSR23 (n = 18) mice at P5. Data are shown as mean ± SEM. Statistical analysis using one-way ANOVA for b, c. Statistical analysis using ANOVA with Bonferroni post hoc test for d. Statistical analysis using a log-rank test for f. Statistical analysis using nonparametric Mann–Whitney test for h, i. *p < 0.05, **p < 0.01, and ***p < 0.001. Source data are provided as a Source Data file

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