Table 1 Hypotheses table

From: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

  Co= Co+Ca Co+Myosin Co+cAMP Co-Ca CoTox
Typical compound Aspirin Ouabain Omecamtiv Mecarbil β-adrenergic agonist Verapamil Doxorubicin (long term)
References 42,43,– 44 15, 45, 46 17, 47, 48 6, 49, 50 51,52,– 53 21, 54, 55
Kinetic parameters       
Action potential (AP)
 Amplitude = = = =
 trise = = NOT ↓
 tAPD = NOT =  = NOT ↑
 Triangulation = =
Calcium transient (Ca)
 Amplitude = =
 tto peak = NOT ↓ NOT ↑ NOT ↑
 tdecay = NOT ↓ NOT ↑ NOT ↑
Contraction (Co)
 Amplitude =
 tcontraction = NOT ↓ NOT ↑
 trelaxation = NOT ↓ NOT ↓ NOT ↑
  1. Expected effects on kinetic measures of action potential (AP), cytosolic calcium transient (Ca) and contraction (Co) per contractile mechanism of action (MOA). ↓: decrease; ↑: increase; =: no difference. NOT [effect] means all other effects than [effect] might be expected, depending on the specific drug within the MOA category