Fig. 4 | Nature Communications

Fig. 4

From: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Fig. 4

Averaged representative transients of hiPSC-CMs in response to vehicle (DMSO) and drugs. All measurements were normalized to their individual baseline measurements. Cells were paced at 1.2 Hz. Simultaneous measurements show action potential (blue), cytosolic calcium (orange) and contraction (red) of Pluricytes under baseline conditions and in response to 0.3 µM epinephrine (a), 100 µM pimobendan (b), 0.1 µM verapamil (c), 30 µM captopril (d), 3 µM forskolin (e), 30 µM aspirin (f), 3 µM doxorubicin (g), 0.3 µM omecamtiv mecarbil (h), 0.3 µM levosimendan (i), 3 µM atenolol (j), 10 µM sunitinib (k) and 1 µM ouabain (l)

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