Fig. 1 | Nature Communications

Fig. 1

From: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Fig. 1

Schematic of critical mechanisms affecting cardiomyocyte contraction targeted by drugs. Most therapeutics that target the heart or have off-target effects on the heart fall within the mechanisms shown. 1: Since no beta-adrenergic agonists are present in in vitro cultures with defined medium, this category is not relevant in this study. 2: This group is small and the mechanisms are not specific. For example, while blebbistatin reduces contractility, it also affects cardiomyocyte electrophysiology. Therefore, this category is not included in this study. Asterisk: These compounds exhibit both PDE inhibiting and myofilament Ca2+ sensitizing properties, with the dominant mechanism typically depending on the concentration

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