Fig. 7 | Nature Communications

Fig. 7

From: Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Fig. 7

Schematic of aspartate pathway regulation. a Wildtype levels of threonine lead to proper feedback regulation of Ask, and subsequent wildtype levels of lysine and its degradation (Lat/Pcd) and export (LysE) pathway enzymes and metabolites. b Disruption of threonine biosynthesis causes derepression of Ask leading to an accumulation of Lysine, which in turn activates the lysine degradation and export pathways. Nomenclature: Metabolites in rounded boxes: Asp: aspartate, Asp-P: aspartate-phosphate, ASA: aspartate-semialdehyde, Hse: Homoserine, Hse-P: homoserine-phosphate, Thr: Threonine, HsE-O-Ac: O-acetyl-homoserine, Met: methionine, Lys: lysine, AAA: aminoadipate, Enzymes: Ask: aspartate kinase, Asd: aspartate semidaldehyde dehydrogenase, ThrA: homoserine dehydrogenase, ThrB: threonine kinase, ThrC: threonine synthase, MetX: homoserine O-acetyl-transferase, LysE: lysine exporter, Lat: lysine aminotransferase, Pcd:  aminoadipate-semialdehyde dehydrogenase. Genes in square boxes. Color coding: green: wildtype levels, blue: reduces levels, red: increased levels

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