Fig. 5 | Nature Communications

Fig. 5

From: Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Fig. 5

Ultrasound (US) images of the ISFI after subcutaneous injection. ISFI formulation containing 1:2 w/w PLGA/NMP was injected (65 µL) s.c. into nude (nu/nu) mice (n = 7) and imaged using volumetric ultrasound. Images illustrate 2D slices from one plane through the same subcutaneous implant volume at days 0 and 2 (a, b, respectively). The black center region (yellow arrow) indicates the portion of the implant remaining in the liquid state (presumably, NMP solvent), which decreased after initial injection. c is the same implant as b, except with green arrows delineating the outer implant boundary, indicated by a fine grayscale demarcation in the ultrasound image. Volume measurements were obtained by a reader who measured the approximate implant dimensions on two orthogonal image planes, resulting in length, width and depth measurements to estimate ellipsoid volume (volume of the liquid core was not separately quantified in this study). Scale bars indicate 1 mm

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