Fig. 1 | Nature Communications

Fig. 1

From: Extreme inbreeding in a European ancestry sample from the contemporary UK population

Fig. 1

Predictive performances of FROH to discriminate different types of inbreeding: mating type 1 (MT1: parent-offspring or fullsibs mating), mating type 2 (MT2: halfsibs, avuncular, grandparent-grandchild or double-first cousins mating) or mating type 3 (MT3: first-cousins mating). Panels a and c correspond to the comparison of MT1 and MT2, while panels b and d correspond to the comparison of MT1 and MT2 on the one hand and MT3 on the other hand. Predictive statistics assessed are the area under the receiver characteristics operating curve (AUC), the sensitivity to detect MT1 over MT2 (true positive rate) and specificity to distinguish MT1 from MT2 (true negative rate). FROH>0.17 yields a sensitivity and specificity >0.92 to discriminate MT1 from MT2; and FROH>0.087 yields a sensitivity of ~0.94 and a specificity of ~0.79 to discriminate MT1 or MT2 from MT3

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