Fig. 4 | Nature Communications

Fig. 4

From: Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

Fig. 4

Effect of bimodal dendritic integration on neuronal firing. Firing rate responses (in Hz) from one hippocampal (a,c) and one PFC (b,d) model cell, in response to stimulation of increasing numbers of synapses (10–60) that are either randomly distributed throughout the entire dendritic tree (blue) or grouped within a few dendritic branches (pink). Synapses are stimulated with a 50 Hz Poisson spike train. In both cases, dispersed activation leads to higher firing rates. e, f Same as in c, d with dendritic diameter set to 2 μm and removal of A-type dendritic channels. Firing rates are indistinguishable between grouped and dispersed activation patterns. Insets depict representative traces from dispersed (top) and grouped (bottom) activation of 30 synapses. Red dots in a, b, show the synaptic allocation motif

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