Table 2 Association of the 14 identified metabolic biomarkers with all-cause mortality in the fully adjusted model

From: A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Biomarker Full name HR 95% CI P I 2 P (het)
XXL-VLDL-L Total lipids in chylomicrons and extremely large VLDL 0.80 0.75–0.85 1.53 × 10−13 0.08 0.363
S-HDL-L Total lipids in small HDL 0.87 0.84–0.90 5.98 × 10−19 0.52 0.018
VLDL-D Mean diameter for VLDL particles 0.85 0.80–0.90 8.51 × 10−8 0.21 0.241
PUFA/FA Ratio of polyunsaturated fatty acids to total fatty acids (%) 0.78 0.75–0.80 1.06 × 10−47 0.71 8.65 × 10−5
Glc Glucose 1.16 1.13–1.19 2.22 × 10−29 0.56 0.008
Lac Lactate 1.06 1.03–1.10 6.24 × 10−5 0.28 0.173
His Histidine 0.93 0.90–0.96 1.15 × 10−5 0.24 0.213
Ile Isoleucine 1.23 1.14–1.32 2.14 × 10−8 0.39 0.078
Leu Leucine 0.82 0.76–0.89 7.34 × 10−7 0.35 0.109
Val Valine 0.87 0.82–0.92 1.04 × 10−6 0.07 0.376
Phe Phenylalanine 1.13 1.09–1.17 2.39 × 10−12 0.44 0.052
AcAce Acetoacetate 1.08 1.05–1.11 1.73 × 10−8 0.35 0.108
Alb Albumin 0.89 0.87–0.92 9.96 × 10−13 0.52 0.017
GlycA Glycoprotein acetyls 1.32 1.27–1.38 7.45 × 10−41 0.45 0.046
  1. HR hazard ratio, CI conference interval, P P value, I2 heterogeneity statistic, het heterogeneity, VLDL very low-density lipoprotein particle, HDL high-density lipoprotein. The statistics in this Table have been generated with the R-package meta using the survival analyses results from the individual cohorts as input