Fig. 8 | Nature Communications

Fig. 8

From: Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels

Fig. 8

Model diagram of how stromal Sfrp3 regulates MG epithelial morphogenesis. In wild-type mammary gland SFRP3(+/+) secreted by the stroma binds to Wnt2, likely contributing to diffuse the high level of stromal Wnt2 expression at the boundary. The crosstalk between stroma and epithelium is correct, allowing luminal cells to properly polarise and organise as a monolayer. Ducts branch appropriately during puberty. In the absence of Sfrp3(−/−) stromal level of Wnt2 concentrates at the boundary. The stromal–epithelial communication is altered, resulting in altered arrangement of luminal cells, that are less polarised, overproliferate and produce β casein. Total levels of Wnt2 expression is reduced. Overall ducts are longer and hyperbranched. BM, basement membrane

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