Fig. 5 | Nature Communications

Fig. 5

From: XX sex chromosome complement promotes atherosclerosis in mice

Fig. 5

Intestinal gene expression, triglyceride content, and fat absorption are higher in XX than XY Ldlr−/− mice. mRNA abundance of Dgat2 (a) (FXX, n = 4; FXY, n = 5; MXX, n = 5; MXY, n = 5) and Mttp (b) (FXX, n = 4; FXY, n = 5; MXX, n = 5; MXY, n = 5) in small intestines from gonadectomized (GDX) male and female XX and XY mice. c Intestinal triglyceride content in GDX XX and XY male and female mice (FXX, n = 4; FXY, n = 5; MXX, n = 5; MXY, n = 5). d Fatty acids (Palmitic/palmitic/oleic acids) that are enriched in intestinal triglycerides from XX compared to XY GDX mice (FXX, n = 4; FXY, n = 5; MXX, n = 5; MXY, n = 5). e Absorption of dietary fat (%) in XX and XY male and female mice. Symbols represent individual mice per group per measurement, with horizontal lines representing mean ± SEM (n = 5 mice/genotype/sex). *P < 0.05 compared to XX within gonadal sex. #P < 0.05 compared to female within genotype. @P < 0.05 XX vs. XY. f Overall conclusions from this study. Data (ad) were analyzed by 2-way ANOVA with Holm–Sidak test. Dietary fat absorption data (e) were analyzed by Kruskal–Wallis. Source data are available as a Source Data file

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