Fig. 2 | Nature Communications

Fig. 2

From: XX sex chromosome complement promotes atherosclerosis in mice

Fig. 2

An XX sex chromosome complement promotes obesity and dyslipidemias. a Body weights (gm) of male and female intact and gonadectomized (GDX) mice of each genotype (Intact: FXX, n = 11; FXY, n = 14; MXX, n = 9; MXY, n = 11; GDX: FXX, n = 9; FXY, n = 8; MXX, n = 7; MXY, n = 7). b Representative pictures of mice from each group (left), with adipose tissue depots illustrated. c Representative pictures of serum from XX and XY male mice. d Total serum cholesterol concentrations (Intact: FXX, n = 10; FXY, n = 12; MXX, n = 9; MXY, n = 11; GDX: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5). Concentrations of very low density lipoprotein (VLDL)-cholesterol (e) (Intact: FXX, n = 6; FXY, n = 6; MXX, n = 5; MXY, n = 6; GDX: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5), low density lipoprotein (LDL)-cholesterol (f) (Intact: FXX, n = 6; FXY, n = 6; MXX, n = 5; MXY, n = 6; GDX: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5) and high density lipoprotein (HDL)-cholesterol (g) (Intact: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5; GDX: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5) and TG (h) (Intact: FXX, n = 4; FXY, n = 6; MXX, n = 4; MXY, n = 5; GDX: FXX, n = 6; FXY, n = 4; MXX, n = 6; MXY, n = 5) in Ldlr−/− mice fed a Western diet for 4 months. Concentrations of total serum cholesterol (i) (FXX, n = 11; FXY, n = 10; MXX, n = 12; MXY, n = 8), LDL-cholesterol (j) (FXX, n = 11; FXY, n = 10; MXX, n = 12; MXY, n = 8), HDL-cholesterol (k) (FXX, n = 11; FXY, n = 10; MXX, n = 12; MXY, n = 8) and TG (l) (FXX, n = 11; FXY, n = 10; MXX, n = 12; MXY, n = 8) in Apoe−/− mice fed a standard murine diet. Symbols represent individual mice per group per measurement, with horizontal lines representing mean ± SEM. *P < 0.05 compared to XX within gonadal sex. #P < 0.05 compared to female within sex chromosome complement. $P < 0.05 compared to XX females. Data were analyzed by 3-way ANOVA (a, dh) with Holm–Sidak test, or by 2-way ANOVA (il) with Holm–Sidak test. Source data are available as a Source Data file. RPF retroperitoneal, EF epididymal, SubQ subcutaneous

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