Fig. 1 | Nature Communications

Fig. 1

From: XX sex chromosome complement promotes atherosclerosis in mice

Fig. 1

XX male and female mice have higher body weight, fat mass and food intake. a Body weight of mice of each sex chromosome complement and gonadal sex at baseline (when fed standard murine diet) or after 1 week of consumption of a Western diet (WD). Lean (b) and fat (c) mass (gm). d Food intake, normalized to lean mass, of mice fed standard murine diet. e Physical activity, normalized to lean mass, of mice fed standard murine diet. f Energy expenditure, normalized to lean mass, of mice fed standard murine diet. g Food intake, normalized to lean mass, of mice fed a Western diet (1 week). h Physical activity, normalized to lean mass, of mice fed a Western diet. i Energy expenditure, normalized to lean mass, of mice fed a Western diet. Symbols represent individual mice per group (n = 5 mice/group) per measurement, with horizontal lines representing mean ± SEM. *P < 0.05 compared to XX within gonadal sex. #P < 0.05 compared to female within sex chromosome complement. $P < 0.05 compared to XX females. @P < 0.05 main effect of sex chromosome complement. Data were analyzed by 3-way ANOVA (A-C) with Holm–Sidak test, or by 2-way ANOVA (di) with Holm–Sidak test. Source data are available as a Source Data file

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