Fig. 7 | Nature Communications

Fig. 7

From: Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Fig. 7

In vivo synthetic lethal interactions between PARP inhibition and cancer cell senescence. a Treatments time line of OV4453, OV1946 and MDA-MB-231. b Changes of OV4453, OV1946, and MDA-MB-231 tumor size after Olaparib (green, n = 12 for OV4453 and OV1946; n = 16 for MDA-MB-231), ABT-263 (orange, n = 7 for OV4453 and OV1946; n = 16 for MDA-MB-231), combination Olaparib + ABT-263 (red, n = 10 for OV4453 and OV1946; n = 16 for MDA-MB-231) or DMSO (blue, n = 8 for OV4453 and OV1946; n = 16 for MDA-MB-231). c Tumor size ratio between the first and the last day of treatment for each xenograft. d, e Representative images (d) and quantification (e) of γ-H2AX foci per nucleus in OV4453, OV1946, and MDA-MB-231 xenografts harvested two weeks after the first day of treatment. Scale bar, 100 µm. Data in (c) were analyzed using the two way ANOVA test with Bonferroni post-test correction. Complete statistics are supplied in Supplementary Tables 1–3. Data in (e) were analyzed using the two-tail Student t test. *Denotes p < 0.05, **p < 0.01, and ***p < 0.001

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