Fig. 5 | Nature Communications

Fig. 5

From: Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

Fig. 5

Replication of methylation probes associated with kidney function decline 471 methylation probes significantly improved the baseline kidney function decline weighted linear regression model beyond baseline variables (Age, baseline GFR, and Diabetes) (AIC < 206 and FDR < 0.05). Of these 471 probes, 432 probes were assessed in the replication cohort in peripheral blood. 39 probes were excluded due to poor data quality. 52 methylation probes were associated with Adjusted GFR slope when adjusted for Age, Sex, reaching end stage renal disease (ESRD), duration of diabetes, mean blood pressure, hemoglobin A1C, as well as cell type heterogeneity using linear regression (p-value < 0.05). Of these 52 probes, 25 probes maintained directional consistency across the two data sets

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