Table 1 Protonation Constants of Ligands and Uranyl Chelation Stability Constants

From: A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

Protonation Constants EDTA(LeH4) LcH2a LH2  
pKa1 2.1(3) 5.91 8.3(5)  
pKa2 2.7(1) 7.14 9.3(4)  
pKa3 6.1(1)    
pKa4 9.8(1)    
Ligand Species m, l, h Logβmlh pUO2b
5LIO-1-Cm-3,2-HOPO(L) UO2LH+ 1, 1, 1 24.8(7) 16.6(5)
  UO2L 1, 1, 0 18.6(7)  
  UO2L(OH) 1, 1, -1 7.5(7)  
5LIO-(Me-3,2-HOPO)(Lc)a UO2LcH+ 1, 1, 1 18.4 15.7
  UO2Lc 1, 1, 0 14.9  
  UO2Lc(OH) 1, 1, -1 6.3  
  1. aData from ref 29
  2. bpM = -log [Mfree]; [M] = 10−4 M and [L] = 10−3 M
  3. 5LIO-(Me-3,2-HOPO) denoted Lc, EDTA denoted Le.