Fig. 1 | Nature Communications

Fig. 1

From: Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Fig. 1

HARs interact with genes that regulate human brain development. a DHS enrichment of HARs in different cell/tissue types after controlling for evolutionary conservation (Methods). HSCs, hematopoietic stem cells; NK cells, natural killer cells; DLPFC, dorsolateral prefrontal cortex. P-values and odds ratio calculated by Fisher’s exact test. Error bars denote for 95% confidence intervals (CI). b Overlap between nearest genes to HARs (closest) with genes that interact with HARs in developing brain (fetal brain). c Overlap between genes that interact with HARs in developing brain (fetal brain), and non-neuronal cell types (non-neurons)10. Protein-coding genes were used for Venn diagrams. d Gene ontology enrichment for HAR-associated genes

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