Fig. 8 | Nature Communications

Fig. 8

From: Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Fig. 8

Association between CSF-Aβ34 and Aβ clearance rates. Analysis of Aβ34, Aβ38, Aβ40, and Aβ42 in human CSF with ultra-sensitive assays (Meso Scale Discovery (MSD)). Aβ38, Aβ40, and Aβ42 clearance (fractional turnover rate, FTR) was previously measured using stable isotope labeling kinetic (SILK)31. Samples were from n = 10 Aβ+ and n = 10 Aβ– individuals. Scatterplots of CSF-Aβ34 (ac), Aβ38 (df), Aβ40 (gi), or Aβ42 (jl) with Aβ38 FTR (a, d, g, j), Aβ40 FTR (b, e, h, k), or Aβ42 FTR (c, f, i, l). Pearson correlation coefficients (r) were computed to assess the relationship between the variables. The Bonferroni adjusted p-values are: **p < 0.003, *p < 0.016, ns = nonsignificant p > 0.0125

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