Table 3 Antagonistic interactions

From: Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent

Molecule Activity Drosophila Vertebrate
H3K27me3 Inhibits TRXG binding   Human SET1 and MLL1 complexes bind poorly to H3K27me3 histones. Catalytic activity is not prevented134
H2Aub Inhibits TRXG activity   Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases45.
H3K4/K36me Inhibits PRC2 activity H3K4 and H3K36 methylation inhibit PRC2 H3K27 methylation activity43,44 H3K4 and H3K36 methylation inhibit PRC2 H3K27 methylation activity32,44.
PRC1 and CBP PC inhibits CBP activity Polycomb (PC, subunit of PRC1) inhibits histone acetylation mediated by CBP by binding directly to the CBP catalytic domain133  
PRC2 and KDM Interact physically and functionally   PRC2 recruits RBP2 (H3K4 demethylase)111 and LSD1 (H3K4 demethylase)135
PRC1 and KDM Interact physically and functionally Non-canonical PRC1 complex dRAF contains dRING (ubiquitin ligase) and dKDM2 (H3K4 and H3K36 demethylase)115,91 Non-canonical PRC1 complex PRC1.1 contains dRING (ubiquitin ligase) and KDM2B (H3K4 and H3K36 demethylase)86,114,92
TRXG and UTX Interact physically and functionally UTX (H3K27 demethylase) is associated with CBP and the TrxG protein BRM139 UTX (H3K27 demethylase) is associated with MLL 2/3 (vertebrate homologs of TRX)46