Fig. 3 | Nature Communications

Fig. 3

From: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes

Fig. 3

A histological analysis of the patent or rejected HOBPTs at 2 weeks after transplantation. The lumen of the HOBPT in the CISP group was completely obstructed by thrombus a, b, but was patent in the OIDPs h, i. The lymphocyte infiltration in the HOBPT of the OIDP group j, k was drastically inhibited in comparison with the CISP group c, d. Immunohistochemically, the numbers of CD45 + common lymphocytes e, l, CD20 + B lymphocytes f, m and CD3 + T lymphocytes g, n in the OIDP group l–n were significantly decreased in comparison with the CISP group e–g. Scale bar: 1 mm in b, i, 200 µm in c, j, 50 µm in d–g, k–n. HOBPT: human original 3D bioprinted tube, CISP: conventional immunosuppressive pig, OIDP: operational immunodeficient pig

Back to article page