Fig. 1 | Nature Communications

Fig. 1

From: Single-molecule kinetics of pore assembly by the membrane attack complex

Fig. 1

Formation of MAC on bacterial model membranes. a 3D AFM representation of the endpoint MAC pore structure on supported bilayers composed of an E. coli lipid extract. Inset: Schematic of the MAC, self-assembled from complement proteins C5b6, C7, C8 and C9, embedded within a lipid membrane. b Zoom-in of a single MAC pore (marked with an asterisk in a). c Negative-stain EM of E. coli lipid bilayers deposited on silicon dioxide grids, sequentially incubated with complement proteins C5b6, C7, C8 and C9, resulting in characteristic MAC rings observed in the bilayer membrane. Scale bars: a, c 50 nm, b 25 nm. Height scale (scale inset in b), a, b 20 nm

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