Fig. 5 | Nature Communications

Fig. 5

From: Competition for nutrients and its role in controlling immune responses

Fig. 5

Immunological consequences of changes in nutrient signalling. Activation of AMP-activated protein kinase (AMPK) or inhibition of mammalian Target of Rapamycin Complex 1 (mTORC1) signalling promotes the differentiation of regulatory T (TReg) cells over effector T cell subsets (TE), inhibits natural killer (NK) cell functions, and increases the proinflammatory outputs of dendritic cells (DC). Loss of cMyc expression inhibits the functions of TE subsets and NK cells. Activation of general control nonderepressible 2 (GCN2) signalling promotes TReg differentiation, inhibits Th17 differentiation, inhibits CD8 T cell function, and enhances the function of DC. Kynurenine (Kyn)-mediated aryl hydrocarbon receptor (AhR) signalling promotes the differentiation of TReg

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