Fig. 1 | Nature Communications

Fig. 1

From: Competition for nutrients and its role in controlling immune responses

Fig. 1

Metabolism configured to support energy homoeostasis and biosynthesis. Cellular metabolism can be configured to efficiently generate energy in the form of ATP. Glucose is metabolised by aerobic glycolysis (red) and via glycolysis coupled to the tricarboxylic acid (TCA) cycle (purple) to drive oxidative phosphorylation (OXPHOS) (blue) and the generation of energy in the form of ATP. Additional fuels, including fatty acids and the amino acid glutamine, can be used to support OXPHOS. Various other amino acids can also feed into both glycolysis and the TCA cycle. In addition to fuelling energy production, glucose and amino acids can be metabolised and used to support biosynthetic processes (green). Intermediates of glycolysis and the TCA cycle can be diverted into metabolic pathways to generate biosynthetic precursors important for the synthesis of lipids, nucleotides and proteins. Fatty acids can also be directly used for biosynthesis

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