Fig. 4 | Nature Communications

Fig. 4

From: A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

Fig. 4

Hemostatic properties of the matrix gel in a pig cardiac puncture injury model. a Schematic diagram of the surgical procedure. b Gross view of the rapid hemostasis and sealing following cardiac puncture injury: the ventriculus sinister of the pig hearts was pierced by a 6 mm (inner diameter) needle, causing immediate high-pressure blood expulsion, subsequently continuing blood expulsion following needle removal. Then, the matrix gel was injected to cover the blood hole and rapidly irradiated with UV. After UV-induced rapid polymerization, the bleeding stopped completely within 10 s (four experimental operations were carried out). c Scanning electron micrographs of the interface between the pig heart puncture wound and the hydrogel. These sections derive from immediate postoperative autopsy on the heart of one pig, which was immediately killed after successful hemostatic treatment. Scale bar: 50 μm (left plates); 10 μm (right plates, enlarged). d Images of a heart autopsy following killing after two 2 weeks of postoperative recovery, the hydrogel still adhering to the wound, without any gap between gel and tissues, indicating continuous strong bonding at the healing interfaces. e Tissue staining images of the interface between pig heart cardiac tissue and the matrix gel, after 2 weeks of postoperative recovery. Scale bar: 200 μm (n = 4) Source data are available in the Source Data file

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