Fig. 7 | Nature Communications

Fig. 7

From: Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Fig. 7

Post-hoc analysis of putative synergy biomarkers. a Synergy markers suggested by DMIS and NAD, when focusing on top weighted features from predictive models filtered for biological relatedness to drug targets, ANOVA with FDR of triple asterisks refers to 5%, double asterisks refers to 20% and single asterisks to 35%. b Venn-diagram showing independent and overlapping cell lines between AZ-DREAM and O’Neil et al.4. Independent dataset reproducibility of biomarker predictions in c the overlapping and d O’Neil et al.4 exclusive cell lines. The effect size is the mean difference in synergy scores of mutant vs. wild-type cell lines. e Comparison of ADAM17 combined with PIK3CB/D against ADAM17 in combination with pan-PIK3C inhibitor. f Network cartoon of PI3K signaling and role of ADAM17

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