Fig. 6 | Nature Communications

Fig. 6

From: Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Fig. 6

Drug synergy and monotherapy resistance biomarker relationship. a Cell lines and b PDX models show increased frequency of synergistic drug combinations if they contain biomarkers with stronger association to monotherapy resistance (Methods; Supplementary Methods). The fraction of combination experiments is selected by order of most significant linked monotherapy resistance biomarker associations. The solid and dashed line are the LOcal regrESSion (LOESS) curve fit and its standard error, respectively

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