Fig. 6 | Nature Communications

Fig. 6

From: Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Fig. 6

A schematic model of the generation and toxicity of PS. In gut microbiota, TPL converts tyrosine to phenol and ammonia. PS is also generated in the liver. PS accumulates in plasma as a metabolite and has deleterious effects on the vasculature and kidneys. In diabetic kidney disease, PS damages podocytes, accelerates GBM thickening, and induces proteinuria. Treatment with TPL inhibitors reduces plasma PS levels and prevents the progression of renal failure in animal models

Back to article page