Fig. 3 | Nature Communications

Fig. 3

From: Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Fig. 3

The clinical significance of PS in DKD patients. a The relationship between the plasma PS concentration (n = 362). b The relationship between the plasma PS concentration and the urinary albumin level (n = 362). c The relationship between the plasma PS concentration and the eGFR (n = 362). d The relationship between the plasma PS concentration and soluble urokinase-type plasminogen activator receptor (suPAR) (n = 362). e PS is a predictor of 2-year albuminuria. Adjusted odds ratio (95% confidence interval). Note that, among the known factors23, PS was the only factor that served as a predictor of the progression of 2-year ACR in patients with microalbuminuria (n = 87). Receiver operating characteristic (ROC) curve analysis in the U-CARE Study, showing comparison of known factors23. f AUC-ROC using known factors (0.713) and adjusted with PS (0.751) (n = 87). g AUC-ROC using known factors (0.713) and adjusted with suPAR (0.725). (n = 87). h AUC-ROC using known factors with suPAR (0.725) and adjusted with PS (0.752) (n = 87)

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